Simulation of Mechanical Properties and Intracellular Pressure of Erythrocyte According to Atomic Force Microscopy

Authors Yu.S. Nagornov1 , I.V. Zhilyaev2

1 Togliatti State University, 14b, Belorusskaya St., 445667 Togliatti, Samara region, Russia

2 Southern Federal University, 105/42, Bolshaya Sadovaya St., 344006 Rostov-on-Don, Russia

Issue Volume 7, Year 2015, Number 4
Dates Received 29 September 2015; published online 10 December 2015
Citation Yu.S. Nagornov, I.V. Zhilyaev, J. Nano- Electron. Phys. 7 No 4, 04030 (2015)
PACS Number(s) 64.75.g , 87.17.Aa
Keywords AFM (18) , Modeling of the mechanical properties, Intercellular pressure (2) , Erythrocytes.
Annotation In the paper we carry out the calculation mechanical properties and intracellular pressure of erythrocytes by finite element method and comparison of these data to the experimental data obtained using atomic force microscopy. The paper proposes a model of the erythrocyte representing the erythrocyte as a homogeneous elastic body with the elasticity depending on the distance to the center of the erythrocyte. The model is based on data from atomic force microscopy obtained by various authors, in particular the data on rigidity of the membrane, which depends on the position of the measuring point on the surface. The good agreement between calculated and experimental data confirms the consistency of the model and allows us to conclude that the morphology of the erythrocyte is largely determined by the elastic properties of the membrane and intercellular pressure.

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