Structure and Morphology of Nanocrystalline Calcifications in Thyroid

Authors S.N. Danilchenko1 , A.S. Stanislavov1 , V.N. Kuznetsov1 , A.V. Kochenko1, T.G. Kalinichenko1, A.V. Rieznik2, V.V. Starikov3 , R.A. Moskalenko2, A.M. Romaniuk2

1 Institute for Applied Physics, NAS of Ukraine, 58, Petropavlovskaya St., 40000 Sumy, Ukraine

2 Sumy State University, 2, Rymskogo-Korsakova St., 40007 Sumy, Ukraine

3 National Technical University «Kharkiv Politechnic Institute», 21, Frunze St., 61002 Kharkiv, Ukraine

Issue Volume 8, Year 2016, Number 1
Dates Received 12 February 2016; revised manuscript received 02 March 2016; published online 15 March 2016
Citation S.N. Danilchenko, A.S. Stanislavov, J. Nano- Electron. Phys. 8 No 1, 01031 (2016)
DOI 10.21272/jnep.8(1).01031
PACS Number(s) 87.15. ± v
Keywords Calcification, Thyroid gland, Structure (102) , Phase composition (3) , Apatite.

The paper presents the results of study on morphology, structure, elemental and phase composition of the calcified fragments from pathological formations of the thyroid gland. The X-ray diffraction and infrared spectroscopy revealed that all investigated pathological calcifications are represented by a defective carbonate substituted calcium apatite Ca10(PO4)6(OH)2. The use of transmission electron microscopy in combination with electron microdiffraction is shown to reveal some structural and morphological features of crystals of thyroid apatite, which are not detectable by other methods. Therefore, the local morphological and structural analysis of a mineral component of the deposits can be implemented both in one clinical case, and in wide variety of cases, if a delicate preparation at anatomical studies and sample preparation procedure will be applied.