Evaluating Next-Generation Nanobiosensors for Detecting Dangerous Biological Markers in Diseases

Authors D. Pal1, P. Ghosh1, S. Das1 , I. Saha2, S. Biswas2, S. Chandra2
Affiliations

1Narula Institute of Technology, 700109 Kolkata, India

2Guru Nanak Institute of Technology, 700114 Kolkata, India

Е-mail dppalit@gmail.com
Issue Volume 18, Year 2026, Number 2
Dates Received 02 February 2026; revised manuscript received 25 April 2026; published online 29 April 2026
Citation D. Pal, P. Ghosh, et al., J. Nano- Electron. Phys. 18 No 2, 02015 (2026)
DOI https://doi.org/10.21272/jnep.18(2).02015
PACS Number(s) 87.85.fk
Keywords Biosensing technologies, Nanoscale innovations, Critical diseases, Advanced nanobiosensor systems.
Annotation

The emergence of a novel human coronavirus in 2019 and its swift global transmission led to a pandemic that heightened morbidity and highlighted the limitations of existing diagnostic approaches, which are often labor-intensive, slow, and non-portable. In contrast, biosensors (BS) offer a promising alternative by enabling rapid, cost-effective, accurate, selective, and sensitive detection of numerous illnesses. Their ability to quickly identify a wide spectrum of viruses allows timely medical intervention. Recent progress in nano-technology has further enhanced diagnostic capabilities through the development of advanced nanobiosensors (NBS), compact and intelligent devices that have transformed viral detection due to their portability, robustness, and affordability. This review provides an in-depth assessment of the biosensor technologies employed for virus identification, with particular emphasis on the role of NBS in detecting COVID-19. It also explores the challenges and future prospects associated with designing ultrahigh-sensitivity NBS before establishing them as the next-generation gold standard in diagnostics. Overall, these innovations hold substantial potential to advance medical diagnosis and improve treatment evaluation.

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