Application of Nanocomposite Coatings with Different Structural Physical and Chemical Characteristics in Tissue Engineering

Authors A.N. Goltsev1, I.V. Rassokha1, T.G. Dubrava1, L.V. Ostankova1, M.V. Ostankov1, E.A. Gordienko1, V.I. Safonov2 , A.V. Zykova2

1 Institute for Problems of Cryobiology & Cryomedicine of the National Academy of Sciences of Ukraine, 23, Pereyaslavskay Str., 61015 Kharkov, Ukraine

2 National Science Center “Kharkоv Institute of Physics and Technology” of the National Academy of Sciences of Ukraine, 1, Akademicheskaya Str., 61108 Kharkov, Ukraine

Issue Volume 5, Year 2013, Number 1
Dates Received 15 November 2012; revised manuscript received 30 January 2013; published online 28 March 2013
Citation A.N. Goltsev, I.V. Rassokha, T.G. Dubrava, et al., J. Nano- Electron. Phys. 5 No 1, 01008 (2013)
PACS Number(s) 81.15. – z, 87.85.Lf
Keywords Nanocomposite coatings, Mesenchymal stem cells, ido gene.
Annotation The research covers the results of experimental studies of the effect character of nanocomposite coatings with different physical and chemical parameters (type, roughness, hydrophilic-hydrophobic characteristics) on structural and functional properties (adhesive potential, phenotype, gene expression) of mesenchymal stem cells (MSCs). On the tested nanocoatings (Al2O3, ZrO2, Ta2O5) the capability of oxide coating Al2O3 to enrich the in vitro cultured bone marrow (BM) with the cells of MSCs phenotype markers as well as to increase the expression rate of ido gene in them, which may extend the spectrum of their therapeutic application in clinics, has been found.

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