Injectable Biopolymer-hydroxyapatite Hydrogels: Obtaining and their Characterization
| Authors | L.B. Sukhodub1 , G.O. Yanovska2 , V.M. Kuznetsov2 , O.O. Martynyuk2, L.F. Sukhodub2 |
| Affiliations | 1 SI "Institute of Microbiology and Immunology, the Mechnikov I.I. AMS of Ukraine", 14/16, Pushkinska St., 61057 Kharkiv, Ukraine 2 Sumy State University, 2, Rymskogo-Korsakova St., 40007 Sumy, Ukraine |
| Е-mail | l.sukhodub@gmail.com |
| Issue | Volume 8, Year 2016, Number 1 |
| Dates | Received 21 December 2015; published online 15 March 2016 |
| Citation | L.B. Sukhodub, G.O. Yanovska, V.M. Kuznetsov, et al., J. Nano- Electron. Phys. 8 No 1, 01032 (2016) |
| DOI | 10.21272/jnep.8(1).01032 |
| PACS Number(s) | 87.85.J –, 87.64.Bx, 87.64.Ee |
| Keywords | Hydroxyapatite, Chitosan, Sodium alginate, Hydrogels. |
| Annotation | Hydrogels based on hydroxyapatite (HA) and Chitosan (CS) with addition of sodium alginate (Alg) were synthesized by in situ precipitation method. Structure, morphology, chemical and phase composition of the HA/CS and HA/CS/Alg hydrogels were characterized by TEM, FTIR and XRD. Hydrogels consist of low crystallinity calcium deficient hydroxyapatite (JCPDS 9 432), the needle-like crystallites have an average size 25 nm. The introduction of Alginate powder into HA/CS hydrogel solution demonstrate the viscosity enhancing of the HA/CS hydrogel due to polyelectrolyte reaction between Alginate and Chitosan macromolecules. Two natural polymers and partially released from hydroxyapatite Ca2+ ions formed a matrix by crosslinking the polymer macromolecules through hydroxyl, amino and carbonyl groups. These processes promote the formation of a more stable structure of HA/CS/Alg hydrogel as compared to HA/CS. The structural integrity and degradation tests have demonstrated that HA/CS/Alg1.0 saved its initial shape in 7 days of shaking in SBF solution, meanwhile for HA/CS, a structural decay was observed. The HA/CS hydrogel had completely lost its volume support after 1 day shaking in SBF. Thus, the ability of HA/CS hydrogel to maintain its shape with implantation into bone tissue defect may be enhanced with alginate addition, but alginate content more than 1 w/w % reduces the hydrogel plasticity, increases the swelling and accelerates the shape decay. |
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