Gadolinium Nanoparticles: A Promising Agent for Enhancing Radiotherapy at Low Concentrations
| Authors | L. Benabed1, A.S.A. Dib1, A. Djelloul2 |
| Affiliations |
1Departement of Physics, Faculty of Physics, Laboratory of Analysis and Application of Radiation, Université des Sciences et de la Technologie d’Oran Mohamed Boudiaf, USTO-MB, BP 1505 EL M’naouer, 31000 Oran, Algeria 2Centre de Recherche en Technologie des Semi-Conducteurs pour l’Energétique ‘CRTSE’, 02 Bd Frantz Fanon, BP 140, 7 Merveilles, Alger, Algérie |
| Е-mail | lahouari.benabed@univ-usto.dz |
| Issue | Volume 17, Year 2025, Number 4 |
| Dates | Received 25 April 2025; revised manuscript received 22 August 2025; published online 29 August 2025 |
| Citation | L. Benabed, A.S.A. Dib, et al., J. Nano- Electron. Phys. 17 No 4, 04036 (2025) |
| DOI | https://doi.org/10.21272/jnep.17(4).04036 |
| PACS Number(s) | 07.85.Qe, 71, 79.20.Fv, |
| Keywords | Radiation dose, Nanomaterials (4) , Auger effect, Tumor Dose Absorption, 3D surface topography. |
| Annotation |
Over the last few years, nanomedicine has made significant progress. Nanoparticles are currently being introduced into tumors to enhance treatment, increase the efficiency of drug delivery to tumors, and reduce the toxicity of cancer treatments. The goal of this work is to investigate the improvement of a deep tumor in the center of the human head by radiotherapy, in which nanomaterials were injected in low quantities. Using the Monte Carlo Geant4 code, we built a geometry of a human head in which we placed a spherical tumor with a diameter of 1.3 cm. We are interested in researching the effect of biocompatible nanomaterials added to tumors during X-ray radiotherapy. We focused on the most well-known biocompatible nanomaterials utilized in nanomedicine, including gadolinium (GdNPs), platinum (PtNPs), silver (SvNPs), and gold (AuNPs), particularly at low concentrations. Our findings demonstrate that, in comparison to other nanomaterials, the presence of GdNPs inside the tumor offers the greatest dose absorption at the tumor level upon exposure to 60 keV X-ray radiation, with a performance of 37 %. In comparison to the best-known materials in the literature, such as gold and platinum, our Monte Carlo simulation demonstrates that gadolinium nanoparticles have a high efficiency at low concentrations. |
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List of References |
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