High-Performance Two-Dimensional Photonic Crystal Biosensor to Diagnose Malaria Infected RBCs

Authors H. Tayoub1,2 , A. Hocini1 , A. Harhouz1

1Laboratoire d’Analyse des Signaux et Systèmes, Department of Electronics, University of M’Sila BP.166, Route Ichebilia, 28000 M’Sila, Algeria

2Research Center in Industrial Technologies CRTI, P.O.BOX :64, Cheraga, 16014 Algiers, Algeria

Е-mail hadjira.tayoub@univ-msila.dz
Issue Volume 15, Year 2023, Number 1
Dates Received 05 January 2023; revised manuscript received 16 February 2023; published online 24 February 2023
Citation H. Tayoub, A. Hocini, et al., J. Nano- Electron. Phys. 15 No 1, 01008 (2023)
DOI https://doi.org/10.21272/jnep.15(1).01008
PACS Number(s) 07.07.Df, 42.79.Pw
Keywords Photonic crystal, Ring-shaped cavity, Biosensor (5) , Malaria, Sensitivity (11) , Quality factor.

In this paper, a two-dimensional photonic crystal refractive index biosensor based on a ring-shaped cavity has been proposed. It is designed for the diagnosis of malaria-infected red blood cells (RBCs) in the wavelength range of 1130-1860 nm for TM-polarized light. The proposed biosensor consists of two waveguides coupled with one ring-shaped microcavity, which is obtained by removing seven lattice holes, the microcavity is separated from the two waveguides by three holes. The infiltration of the analyte into the ring-shaped cavity changes its refractive index, and this variation of the refractive index of infected and normal uninfected RBCs causes a corresponding wavelength shift at the output terminal. Consequently, a high sensitivity of more than 700 nm/RIU, an ultra-high-quality factor (Q-factor) of up to 106 giving a sensor figure of merit (FOM) of up to 106 RIU – 1, and a low detection limit of 10 – 7 RIU can be achieved for the proposed design. The proposed device has also an ultra-compact size of 9.78  8.84 m2 that makes it so attractive for lab-on-a-chip applications. The obtained results have demonstrated that the ring-shaped holes configuration provides an excellent optical confinement within the cavity region. The proposed design is simulated using Plane Wave Expansion (PWE) method and Finite-Difference Time-Domain (FDTD) algorithm.

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