A Novel Approach Towards Green Synthesis of Nanodiamonds as Biocompatible Agents

Authors A. Anand1, M. Saran2,3, S. Chaudhary4, R.S. Ronin5, A.K. Swami3, M. Mathur5, A. Burov6,7, A. Bagaria2

1Department of Biotechnology, Mewar University, 312901 Chittorgarh, India

2Department of Physics, Manipal University Jaipur, 303007 Jaipur, India

3Department of Nanobiotechnology, Seminal Applied Sciences Pvt. Ltd, 302015 Jaipur, India

4Department of Chemistry, Malviya National Institute of Technology, 302017 Jaipur, India

5School of Agriculture, Suresh Gyan Vihar University, Mahal Road, 302017 Jaipur, India

6Institute of Computational Technologies SB RAS, 660049 Krasnoyarsk, Russia

7Institute of Biophysics, SB RAS, Akademgorodok, 660036 Krasnoyarsk, Russia

Е-mail manasm407@gmail.com
Issue Volume 13, Year 2021, Number 3
Dates Received 11 January 2021; revised manuscript received 15 June 2021; published online 25 June 2021
Citation A. Anand, M. Saran, et al., J. Nano- Electron. Phys. 13 No 3, 03040 (2021)
DOI https://doi.org/10.21272/jnep.13(3).03040
PACS Number(s) 81.07.Pr, 87.15.N –
Keywords Nanodiamond, Antimicrobial, Green synthesis, Biocompatible agents, Antioxidants.

The application of nanobiotechnology is an emerging area of nanoscience and nanotechnology. Nanodiamond has been a potent antibacterial, antifungal, antioxidant, and antiplatelet agent. In the present study, nanodiamonds were reduced by green synthesis and characterization was done through SEM, TEM, FTIR, and XRD. Further they were tested for their biological applications. The antimicrobial activity was investigated/studied/examined? through well diffusion method. The best activity was observed against Trichoderma reesei (16 mm) at 140 g/ml. The antioxidant activity was investigated through DPPH and FRAPS method. It was observed that the biologically reduced nanodiamonds reduce the Fe3+ ions to Fe2+ ions at 600 mM/l/g concentration. In DPPH assay, inhibitory concentration was found to be 4.58 g/ml. Further the antiplatelet activity was investigated by prothrombin time (PT) and activated partial thromboplastin time (APTT) assay, and it was observed that biologically reduced nanodiamonds have potent antiplatelet activity.

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