Nanocomposite Apatite-biopolymer Materials and Coatings for Biomedical Applications

Authors L.F. Sukhodub1 , G.O. Yanovska2 , L.B. Sukhodub1 , V.M. Kuznetsov2 , O.S. Stanislavov2
Affiliations

1 Sumy State University of Ministry Science and Education of Ukraine, 2, Rymsky-Korsakov St.,40007, Sumy, Ukraine

2 Institute of Applied Physics of National Academy of sciences of Ukraine, 58, Petropavlovska St., 40007, Sumy, Ukraine

Е-mail l_sukhodub@yahoo.com, biophy@yandex.ua, vkuznetsov.ua@gmail.com
Issue Volume 6, Year 2014, Number 1
Dates Received 16 December 2013; published online 06 April 2014
Citation L.F. Sukhodub, G.O. Yanovska, L.B. Sukhodub, et al., J. Nano- Electron. Phys. 6 No 1, 01001 (2014)
DOI
PACS Number(s) 87.85.J –, 87.64.Bx, 87.64.Ee
Keywords Composite biomaterials, Hydroxyapatite, Coatings (10) , Chitosan, Alginate, XRD (76) , XRF, FTIR (26) , SEM (105) , TEM (73) .
Annotation The microoverview paper describes synthesis and characterization of novel third generation composite biomaterials and coatings which correspond to the second structural level of human bone tissue (HBT) organization obtained at Sumy state university “Bionanocomposite” laboratory. To obtain such composites an animal collagen is usually used, which is not potentially safe for medical applications. That is why investigations were started using some other biopolymers to obtain composites close to the second level in the structural hierarchy of HBT. Proposed natural polymers (Na alginate, chitosan) are the most perspective because they have bacteriostatic properties for a vast number of aerobic and anaerobic bacteria, high biocompatibility towards the connective tissue, low toxicity, an ability to improve regenerative processes during wounds healing, degradation ability with the creation of chemotaxic activity towards fibroblasts and osteoblasts. The formation of nanosized (25-75 nm) calcium deficient hydroxyapatite (cdHA) particles in the polymer scaffold approaches the derived material to the biogenic bone tissue, which can provide its more effective implantation. The influence of the imposition of static magnetic field on brushite (CaHPO4·2H2O) crystallization was also investigated. It was shown that changing the magnetic field configuration could greatly affect crystallinity and texture of the derived particles. To increase the biocompatibility of existing medical implants (Ti–6Al 4V, Ti Ni, Mg) the technology for obtaining bioactive coatings with corresponding mechanical, structural and morphology characteristics is developed in our laboratory. In this direction coatings based on cdHA in combination with biopolymer matrices (Na alginate, chitosan,) are obtained in “soft” conditions using a thermal substrate technology. This technology was proposed by Japan scientists [1] and was sufficiently improved by us [2] in order to obtain coatings in the controlled mode.

List of References