Simulation of Mechanical Properties and Intracellular Pressure of Erythrocyte According to Atomic Force Microscopy

Автор(ы) Yu.S. Nagornov1 , I.V. Zhilyaev2

1 Togliatti State University, 14b, Belorusskaya St., 445667 Togliatti, Samara region, Russia

2 Southern Federal University, 105/42, Bolshaya Sadovaya St., 344006 Rostov-on-Don, Russia

Выпуск Том 7, Год 2015, Номер 4
Даты Получено 29.09.2015, опубликовано online – 10.12.2015
Ссылка Yu.S. Nagornov, I.V. Zhilyaev, J. Nano- Electron. Phys. 7 No 4, 04030 (2015)
PACS Number(s) 64.75.g , 87.17.Aa
Ключевые слова AFM (15) , Modeling of the mechanical properties, Intercellular pressure (2) , Erythrocytes.
Аннотация In the paper we carry out the calculation mechanical properties and intracellular pressure of erythrocytes by finite element method and comparison of these data to the experimental data obtained using atomic force microscopy. The paper proposes a model of the erythrocyte representing the erythrocyte as a homogeneous elastic body with the elasticity depending on the distance to the center of the erythrocyte. The model is based on data from atomic force microscopy obtained by various authors, in particular the data on rigidity of the membrane, which depends on the position of the measuring point on the surface. The good agreement between calculated and experimental data confirms the consistency of the model and allows us to conclude that the morphology of the erythrocyte is largely determined by the elastic properties of the membrane and intercellular pressure.

Список литературы