Application Biocomposite Materials Based on Hydroxyapatite and Alginate in Medicine

Author(s) L.F. Sukhodub , A.A. Roshchupkin, L.B. Sukhodub, N.V. Gluschenko

Sumy State University, 2, Rimsky Korsakov Str., 40007 Sumy, Ukraine

Issue Volume 9, Year 2017, Number 4
Dates Received 15 May 2017; published online 27 July 2017
Citation L.F. Sukhodub, A.A. Roshchupkin, L.B. Sukhodub, N.V. Gluschenko, J. Nano- Electron. Phys. 9 No 4, 04017 (2017)
DOI 10.21272/jnep.9(4).04017
PACS Number(s) 42.70.Jk, 82.35. – х
Key words Hydroxyapatite, Alginate, Nanostructured biomaterial, Biocomposite materials.
Annotation Composite materials based on nanocrystalline (100 nm) stoichiometric hydroxyapatite (HA) and calcium deficient HA increased chemical and biological activity in the process of recovery of the affected bone, since HA are the main inorganic components of bone. Sodium alginate is a polymer of natural origin, which has many applications in biomedical science and tissue engineering due to its properties: biocompatibility, hydrophilic, non-immunogenic properties, ability to stimulate osteoplastic processes, ease of gelation. Since alginate gels retain structural similarity to the extracellular matrix of the body, they are especially attractive for wound healing, drug delivery. In the composition of composite materials, it is possible to replace the elastic properties of bone tissue alginate in combination with the mechanical properties of HA and activate the mechanisms of bone tissue regeneration in vivo.The current state of research and the use of biomaterials based on hydroxyapatite and alginate in medicine, pharmacology and tissue engineering are demonsteted in this article.


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